IPSE, a parasite-derived, host immunomodulatory infiltrin protein, alleviates resiniferatoxin-induced bladder pain
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چکیده
منابع مشابه
H-IPSE Is a Pathogen-Secreted Host Nucleus-Infiltrating Protein (Infiltrin) Expressed Exclusively by the Schistosoma haematobium Egg Stage
Urogenital schistosomiasis, caused by the parasitic trematode Schistosoma haematobium, affects over 112 million people worldwide. As with S. mansoni infections, the pathology in urogenital schistosomiasis is mainly related to the egg stage, which induces granulomatous inflammation of affected tissues. Schistosoma eggs and their secretions have been studied extensively for the related S. mansoni...
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212 CYCLOPHOSPHAMIDE-INDUCED CHRONIC CYSTITIS ENHANCES PAIN BEHAVIOR AND BLADDER CAPACITY REDUCTION ELICITED BY RESINIFERATOXIN IN RATS Tomohiko Oguchi, Osamu Nishizawa, Naoki Yoshimura The authors note that while rats with chronic cystitis induced by repeated cyclophosphamide (CYP) injections have been used for basic research of hypersensitive bladder disorders including BPS/IC, changes in pai...
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Parasitic protozoa are among the most important pathogens worldwide. Diseases such as malaria, leishmaniasis, amoebiasis, giardiasis, trichomoniasis, and trypanosomiasis affect millions of people. Humans are constantly threatened by infections caused by these pathogens. Parasites engage a plethora of surface and secreted molecules to attach to and enter mammalian cells. The secretion of lytic e...
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Bladder disorders associated with interstitial cystitis are frequently characterized by increased contractility and pain. The goals of this study were to examine 1) the effects of blocking proteinase-activated receptor-2 (PAR2) on the exaggerated bladder activity and pain evoked by cystitis and 2) the underlying mechanisms responsible for the role of PAR2 in regulating cystic sensory activity. ...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2020
ISSN: 1744-8069,1744-8069
DOI: 10.1177/1744806920970099